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HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.
Genital herpes is classified as a sexually transmitted infection. The diagnosis may be confirmed by viral culture or detecting herpes DNA in fluid from blisters.
People with immature or suppressed immune systems, such as newborns, transplant recipients, or people with AIDS, are prone to severe complications from HSV infections.
HSV infection has also been associated with cognitive deficits of bipolar disorder, and Alzheimer's disease, although this is often dependent on the genetics of the infected person.
In all cases, HSV is never removed from the body by the immune system.
Following a primary infection, the virus enters the nerves at the site of primary infection, migrates to the cell body of the neuron, and becomes latent in the ganglion.
This theory has been contested, however, since HSV is detected in large numbers of individuals having never experienced facial paralysis, and higher levels of antibodies for HSV are not found in HSV-infected individuals with Bell's palsy compared to those without.
In the presence of a certain gene variation (APOE-epsilon4 allele carriers), HSV-1 appears to be particularly damaging to the nervous system and increases one's risk of developing Alzheimer's disease.Herpes cycles between periods of active disease followed by periods without symptoms.The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches.Testing the blood for antibodies against the virus can confirm a previous infection but will be negative in new infections.The most effective method of avoiding genital infections is by avoiding vaginal, oral, and anal sex. Daily antiviral medication taken by someone who has the infection can also reduce spread.Prior HSV-1 seroconversion seems to reduce the symptoms of a later HSV-2 infection, although HSV-2 can still be contracted.